Journal
REPRODUCTION
Volume 152, Issue 5, Pages R159-R166Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/REP-16-0306
Keywords
-
Categories
Funding
- Biomedical Research Unit in Reproductive Health
- University Hospitals Coventry and Warwickshire NHS Trust
- Warwick Medical School
- Tommy's National Miscarriage Research Centre
Ask authors/readers for more resources
Endometrial stem-like cells, including mesenchymal stem cells (MSCs) and epithelial progenitor cells, are essential for cyclic regeneration of the endometrium following menstrual shedding. Emerging evidence indicates that endometrial MSCs (eMSCs) constitute a dynamic population of cells that enables the endometrium to adapt in response to a failed pregnancy. Recurrent miscarriage is associated with relative depletion of endometrial eMSCs, which not only curtails the intrinsic ability of the endometrium to adapt to reproductive failure but also compromises endometrial decidualization, an obligatory transformation process for embryo implantation. These novel findings should pave the way for more effective screening of women at risk of pregnancy failure before conception.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available