Journal
CANCER BIOLOGY & MEDICINE
Volume 14, Issue 3, Pages 212-227Publisher
CHINESE ANTI-CANCER ASSOC
DOI: 10.20892/j.issn.2095-3941.2017.0054
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Funding
- National Basic Research Program of China [973 Program 2014CB931900, 2013CB932503]
- National Natural Science Foundation of China [81373357, 81422048, 81673382, 81521005]
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Multidrug resistance (MDR) is a major obstacle to successful cancer treatment and is crucial to cancer metastasis and relapse. Combination therapy is an effective strategy for overcoming MDR. However, the different pharmacokinetic (PK) profiles of combined drugs often undermine the combination effect in vivo, especially when greatly different physicochemical properties (e.g., those of macromolecules and small drugs) combine. To address this issue, nanotechnology-based codelivery techniques have been actively explored. They possess great advantages for tumor targeting, controlled drug release, and identical drug PK profiles. Thus, a powerful tool for combination therapy is provided, and the translation from in vitro to in vivo is facilitated. In this review, we present a summary of various combination strategies for overcoming MDR and the nanotechnology-based combination therapy.
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