Journal
CELLS
Volume 6, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/cells6030022
Keywords
Atg8a; autophagy; Drosophila; Ref(2)P/p62
Categories
Funding
- Hungarian Academy of Sciences [LP-2014/2]
- National Research, Development and Innovation Office [K 119842, ERC_HU_15 123410, GINOP-2.3.2-15-2016-00032]
- Juan de la Cierva-incorporation grant (Ministerio de Ciencia) [IJCI-2015-24716]
- New National Excellence Program of the Ministry of Human Capacities [UNKP-16-3-III]
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Autophagy is a catabolic process in eukaryotic cells promoting bulk or selective degradation of cellular components within lysosomes. In recent decades, several model systems were utilized to dissect the molecular machinery of autophagy and to identify the impact of this cellular self-eating process on various physiological and pathological processes. Here we briefly discuss the advantages and limitations of using the fruit fly Drosophila melanogaster, a popular model in cell and developmental biology, to apprehend the main pathway of autophagy in a complete animal.
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