Journal
CANCERS
Volume 9, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/cancers9020012
Keywords
interstitial photodynamic therapy; prostate; head and neck; pancreatic; brain; treatment planning
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Funding
- National Cancer Institute of the National Institutes of Health [R01 CA193610]
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Multiple clinical studies have shown that interstitial photodynamic therapy (I-PDT) is a promising modality in the treatment of locally-advanced cancerous tumors. However, the utilization of I-PDT has been limited to several centers. The objective of this focused review is to highlight the different approaches employed to administer I-PDT with photosensitizers that are either approved or in clinical studies for the treatment of prostate cancer, pancreatic cancer, head and neck cancer, and brain cancer. Our review suggests that I-PDT is a promising treatment in patients with large-volume or thick tumors. Image-based treatment planning and real-time dosimetry are required to optimize and further advance the utilization of I-PDT. In addition, pre-and post-imaging using computed tomography (CT) with contrast may be utilized to assess the response.
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