4.6 Review

Targeting PDK1 for Chemosensitization of Cancer Cells

Related references

Note: Only part of the references are listed.
Review Oncology

AGC kinases, mechanisms of regulation and innovative drug development

Alejandro E. Leroux et al.

SEMINARS IN CANCER BIOLOGY (2018)

Review Oncology

PDK1: At the crossroad of cancer signaling pathways

Paolo Armando Gagliardi et al.

SEMINARS IN CANCER BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells

Angela M. Gocher et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biotechnology & Applied Microbiology

Correlation of PDK1 expression with clinicopathologic features and prognosis of hepatocellular carcinoma

Junrong Wang et al.

ONCOTARGETS AND THERAPY (2016)

Article Multidisciplinary Sciences

A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion

Claudio Raimondi et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Phosphoinositide-dependent kinase 1 regulates leukemia stem cell maintenance in MLL-AF9-induced murine acute myeloid leukemia

Tianyuan Hu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Review Biochemistry & Molecular Biology

PDK1: A signaling hub for cell migration and tumor invasion

Paolo Armando Gagliardi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2015)

Review Cell Biology

Regulation of mTORC1 by PI3K signaling

Christian C. Dibble et al.

TRENDS IN CELL BIOLOGY (2015)

Article Cell Biology

TCRP1 contributes to cisplatin resistance by preventing Pol β degradation in lung cancer cells

Xiaorong Liu et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2015)

Review Biotechnology & Applied Microbiology

PI3K and cancer: lessons, challenges and opportunities

David A. Fruman et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Review Biochemistry & Molecular Biology

FOXO transcription factors: key regulators of cellular quality control

Ashley E. Webb et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Article Gastroenterology & Hepatology

Emerging role of the KRAS-PDK1 axis in pancreatic cancer

Riccardo Ferro et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Article Biochemistry & Molecular Biology

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Eeva M. Sommer et al.

BIOCHEMICAL JOURNAL (2013)

Review Biochemistry & Molecular Biology

AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases

Jose M. Arencibia et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)

Review Biochemistry & Molecular Biology

The Importance of the PI3K/AKT/MTOR Pathway in the Progression of Ovarian Cancer

Zachary C. Dobbin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Article Biochemistry & Molecular Biology

Interaction of PDK1 with Phosphoinositides Is Essential for Neuronal Differentiation but Dispensable for Neuronal Survival

Tinatin Zurashvili et al.

MOLECULAR AND CELLULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Activation of PDK-1 maintains mouse embryonic stem cell self-renewal in a PKB-dependent manner

L. S. Ling et al.

ONCOGENE (2013)

Article Multidisciplinary Sciences

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

Run Fan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell Biology

mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in PIK3CA-Mutant Breast Cancer

Moshe Elkabets et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Oncology

The 16p13.3 (PDPK1) Genomic Gain in Prostate Cancer: A Potential Role in Disease Progression

Khalil A. Choucair et al.

TRANSLATIONAL ONCOLOGY (2012)

Review Pharmacology & Pharmacy

PDK1 inhibitors

Elisa Barile et al.

PHARMACEUTICAL PATENT ANALYST (2012)

Article Biochemistry & Molecular Biology

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Ayaz Najafov et al.

BIOCHEMICAL JOURNAL (2011)

Review Biochemistry & Molecular Biology

Targeting PDK1 in Cancer

C. Raimondi et al.

CURRENT MEDICINAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITOR

Kumiko Nagashima et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Cell Biology

TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway

Yixue Gu et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

X. Zhang et al.

ONCOGENE (2011)

Article Multidisciplinary Sciences

Identification of Direct Target Engagement Biomarkers for Kinase-Targeted Therapeutics

Cloud P. Paweletz et al.

PLOS ONE (2011)

Article Biochemistry & Molecular Biology

Cell Signaling by Receptor Tyrosine Kinases

Mark A. Lemmon et al.

Review Cell Biology

The Hippo Signaling Pathway in Development and Cancer

Duojia Pan

DEVELOPMENTAL CELL (2010)

Article Multidisciplinary Sciences

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

Kajsa Ericson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

Elizabeth Iorns et al.

BIOCHEMICAL JOURNAL (2009)

Review Oncology

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

Jeffrey A. Engelman

NATURE REVIEWS CANCER (2009)

Article Biochemistry & Molecular Biology

New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

Christian Peifer et al.

BIOCHEMICAL JOURNAL (2008)

Article Cell & Tissue Engineering

Module map of stem cell genes guides creation of epithelial cancer stem cells

David J. Wong et al.

CELL STEM CELL (2008)

Article Cell Biology

Role of PDK1 in Regulation of Gastric Acid Secretion

Anand Rotte et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2008)

Review Chemistry, Medicinal

Small-Molecule Inhibitors of PDK1

Christian Peifer et al.

CHEMMEDCHEM (2008)

Article Cell Biology

TEAD mediates YAP-dependent gene induction and growth control

Bin Zhao et al.

GENES & DEVELOPMENT (2008)

Article Biochemistry & Molecular Biology

Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

Jose R. Bayascas et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Cell Biology

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE

Sophie Pinner et al.

NATURE CELL BIOLOGY (2008)

Article Gastroenterology & Hepatology

Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse

Ciprian Sandu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Article Biochemistry & Molecular Biology

Evaluation of approaches to generation of tissue-specific knock-in mice

Jose R. Bayascas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN+/- mice

JR Bayascas et al.

CURRENT BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1

RI Feldman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

High frequency of mutations of the PIK3CA gene in human cancers

Y Samuels et al.

SCIENCE (2004)

Review Biochemistry & Molecular Biology

Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation

RM Biondi

TRENDS IN BIOCHEMICAL SCIENCES (2004)

Article Biochemistry & Molecular Biology

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

JT Murray et al.

BIOCHEMICAL JOURNAL (2004)

Article Biochemistry & Molecular Biology

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

D Komander et al.

EMBO JOURNAL (2004)

Article Biochemistry & Molecular Biology

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

EJ McManus et al.

EMBO JOURNAL (2004)

Article Biochemistry & Molecular Biology

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

BJ Collins et al.

EMBO JOURNAL (2003)

Article Biochemistry & Molecular Biology

Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3

S Sato et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Essential role of PDK1 in regulating cell size and development in mice

MA Lawlor et al.

EMBO JOURNAL (2002)

Article Biochemistry & Molecular Biology

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1

N Fujita et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)