Journal
JOURNAL OF CLINICAL MEDICINE
Volume 6, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/jcm6070074
Keywords
Behcet's disease; IL-17; Th17; regulatory T cells; Th1
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Behcet's disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic course and unknown cause. The pathogenesis of BD has not been fully elucidated; however, BD has been considered to be a typical Th1-mediated inflammatory disease, characterized by elevated levels of Th1 cytokines such as IFN-gamma, IL-2, and TNF-alpha. Recently, some studies reported that Th17-associated cytokines were increased in BD; thus, Th17 cells and the IL17/IL23 pathway may play important roles in the pathogenesis of BD. In this chapter, we focus on the pathogenic role of Th17 cells in BD.
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