Journal
JOURNAL OF CLINICAL MEDICINE
Volume 6, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/jcm6010011
Keywords
TGF-beta signaling; TGFBI; gastrointestinal cancer; EMT; tumor promoter; tumor suppressor
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Funding
- Promotion Plan for the Platform of Human Resource Development for Cancer and New Paradigms-Establishing Centers for Fostering Medical Researchers of the Future program - Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Gunma University Initiative for Advanced Research
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Transforming growth factor (TGF)-beta superfamily proteins have many important biological functions, including regulation of tissue differentiation, cell proliferation, and migration in both normal and cancer cells. Many studies have reported that TGF-beta signaling is associated with disease progression and therapeutic resistance in several cancers. Similarly, TGF-beta-induced protein (TGFBI)-a downstream component of the TGF-beta signaling pathway-has been shown to promote and/or inhibit cancer. Here, we review the state of basic and clinical research on the roles of TGF-beta and TGFBI in gastrointestinal cancers.
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