Journal
JOURNAL OF TISSUE ENGINEERING
Volume 8, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/2041731417731546
Keywords
Stent; restenosis; biomolecules; surface modification; re-endothelialization
Categories
Funding
- Basic Science Research Program [2017R1A2B3011121]
- Cell Regeneration Program [2012M2A9C6049717]
- Bio & Medical Technology Development Program [2014M3A9D3033887]
- Korea Institute of Science and Technology (KIST) Program through the National Research Foundation - Ministry of Science, ICT & Future Planning (MSIP) [2E26900]
- International R&D Academy (IRDA) Alumni Partnership Project - KIST, Seoul, Republic of Korea [2Z05100-17-089]
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Cardiovascular diseases are considered as one of the serious diseases that leads to the death of millions of people all over the world. Stent implantation has been approved as an easy and promising way to treat cardiovascular diseases. However, in-stent restenosis and thrombosis remain serious problems after stent implantation. It was demonstrated in a large body of previously published literature that endothelium impairment represents a major factor for restenosis. This discovery became the driving force for many studies trying to achieve an optimized methodology for accelerated re-endothelialization to prevent restenosis. Thus, in this review, we summarize the different methodologies opted to achieve re-endothelialization, such as, but not limited to, manipulation of surface chemistry and surface topography.
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