Journal
ACTA PHARMACEUTICA SINICA B
Volume 7, Issue 1, Pages 3-17Publisher
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2016.11.001
Keywords
Ca2+ channels; Store-operated Ca2+ entry; Cell proliferation; Migration; Apoptosis; Channel blockers; Cancer therapy
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Funding
- NIH [R01-CA185055]
- Sun Yat-sen University [02300-52114000]
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The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca2+ homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis, progression and metastasis. Targeting derailed Ca2+ signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca2+ channels, transporters and Ca2+-ATPases, which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca2+ channels/transporters or Ca2+-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for research
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