Journal
JOURNAL FOR IMMUNOTHERAPY OF CANCER
Volume 5, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s40425-017-0230-9
Keywords
Chimeric antigen receptor T-cells; Adoptive immunotherapy; Tumor microenvironment
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Funding
- American-Italian Cancer Foundation Post-Doctoral Research Fellowship
- NIH [NCI K08CA166039]
- Gabrielle's Angel Foundation
- V Foundation
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Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with CAR T-cells is crucial to improve the potency of adoptive immunotherapy. In this review, we discuss the strategies and potential combinatorial approaches recently developed in mouse models to enhance the efficacy of CAR T-cells, with particular emphasis on the translational potential of these approaches.
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