Journal
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
Volume 14, Issue 3, Pages 391-403Publisher
TAYLOR & FRANCIS INC
DOI: 10.1586/14779072.2016.1128828
Keywords
Atherosclerosis; inflammation; monocytes; T cells; cytokines
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Funding
- Oslo University Hospital, University of Oslo
- K.G. Jebsen Inflammatory Research Center
- Hall Foundation
- South-Eastern Norway Regional Health Authority
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Atherosclerosis is a dynamic, pathogenic process in the artery wall, with potential adverse outcome for the host. Acute events such as myocardial infarction and ischemic stroke often result from rupture of unstable atherosclerotic lesions. Understanding the underlying pathology of such lesions and why and when they rupture, is therefore of great interest for the development of new diagnostics and treatment. Inflammation is one of the key drivers of atherosclerotic plaque development and the interplay between inflammation and lipids constitutes the hallmark of atherosclerotic disease. This review summarizes the role of inflammation in atherosclerosis and presents some of the latest discoveries as well as unmet needs regarding the role of inflammation as major risk factor in atherosclerotic disease.
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