Journal
NATURE MICROBIOLOGY
Volume 3, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41564-017-0072-8
Keywords
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Categories
Funding
- EMBL
- VIB
- Rega institute for Medical Research
- European Research Council [268985]
- MicrobesInside [250172]
- European Community's Seventh Framework Programme via the MetaHIT [HEALTH-F4-2007-201052]
- METACARDIS project [FP7-HEALTH-2012-INNOVATION-I-305312]
- European Union's Horizon research and innovation programme (Marie Sklodowska-Curie grant) [600375]
- Metagenopolis grant [ANR-11-DPBS-0001]
- IHMS project [FP7-HEALTH-2010-single-stage-261376]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P30AI045008] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK050306, UH2DK083981] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R35GM118038] Funding Source: NIH RePORTER
- BBSRC [BB/L027801/1] Funding Source: UKRI
- MRC [MR/L015080/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L027801/1] Funding Source: researchfish
- Medical Research Council [MR/M50161X/1, MR/L015080/1] Funding Source: researchfish
- NNF Center for Basic Metabolic Research [B�ckhed Group, Arumugam Group] Funding Source: researchfish
- Novo Nordisk Fonden [NNF13OC0008163, NNF15OC0016798] Funding Source: researchfish
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Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.
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