Journal
NATURE MICROBIOLOGY
Volume 2, Issue 5, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmicrobiol.2017.57
Keywords
-
Categories
Funding
- Science Foundation Ireland [APC/SFI/12/RC/2273]
- Cremo
- Mead Johnson Nutrition
- Kerry
- General Mills
- GE Healthcare
- Friesland Campina
- Sigmoid
- Alimentary Health
- Second Genome
- Nutricia
- Danone
- Janssen
- AbbVie
- Suntory Morinaga Milk Industry Ltd
- Pfizer Consumer Health
- Radisens
- 4D Pharma
- Crucell
- Adare Pharma
- Artugen Therapeutics
- Caelus
- Cultech Ltd
- Takeda Pharmaceuticals
- Unilever
Ask authors/readers for more resources
The leading probiotics currently available to consumers are generally drawn from a narrow range of organisms. Knowledge of the gut microbiota and its constituent actors is changing this paradigm, particularly given the phylogenetic range and relatively unknown characteristics of the organisms under investigation as novel therapeutics. For this reason, and because their development is likely to be more amenable to a pharmaceutical than a food delivery route, these organisms are often operationally referred to as next-generation probiotics, a concept that overlaps with the emerging concept of live biotherapeutic products. The latter is a class of organisms developed exclusively for pharmaceutical application. In this Perspective, we discuss what lessons have been learned from working with traditional probiotics, explore the kinds of organisms that are likely to be used as novel microbial therapeutics, discuss the regulatory framework required, and propose how scientists may meet this challenge.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available