Journal
NATURE MICROBIOLOGY
Volume 2, Issue 7, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmicrobiol.2017.67
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Funding
- Canadian Natural Sciences and Engineering Research Council [PGSD-3-420434-2012]
- US National Science Foundation Dimensions of Biodiversity [1046153, 1415604]
- US National Institutes of Health [1R01GM108477-01]
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The tricarboxylic acid (TCA) cycle is central to energy production and biosynthetic precursor synthesis in aerobic organisms. There are few known variations of a complete TCA cycle, with the common notion being that the enzymes involved have already evolved towards optimal performance. Here, we present evidence that an alternative TCA cycle, in which acetate: succinate CoA-transferase (ASCT) replaces the enzymatic step typically performed by succinyl-CoA synthetase (SCS), has arisen in diverse bacterial groups, including microbial symbionts of animals such as humans and insects.
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