Journal
TRENDS IN CANCER
Volume 2, Issue 11, Pages 664-675Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2016.10.002
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Funding
- US-Israel Bi-National Science Foundation [2011244]
- Israel Science Foundation [955/11]
- Israel Cancer Research Foundation Research Career Development Award
- Israel Cancer Association [20150002]
- Israel Ministry of Health [3-10117]
- Boaz and Varda Dotan Center Grant for Hemato-oncology Research
- Tel Aviv University
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Eosinophils are evolutionary conserved cells largely studied in the context of allergy. Although eosinophils were first described in tumors more than 120 years ago, their roles in cancer are often overlooked. This is puzzling given their potent immune modulatory, cytotoxic, and/or tissue repair capabilities, and recent studies demonstrating key roles for eosinophils in contexts far beyond their 'classical' field (e.g., metabolism, thermogenesis, and tissue regeneration). Recent data suggest that this frequently ignored cell is emerging as a potent immune effector and immune modulator in the tumor microenvironment. This review discusses the relevance of eosinophils to tumorigenesis and the potential to harness their function in cancer therapies.
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