Journal
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
Volume 2, Issue 6, Pages 733-749Publisher
ELSEVIER INC
DOI: 10.1016/j.jcmgh.2016.09.002
Keywords
VEGF; Inflammation; Cirrhosis; Portal Hypertension
Categories
Funding
- National Institutes of Health [R01 DK082600, R21AA023599]
- Connecticut DPH [2015-0901]
- Uehara Memorial Foundation
- International Research Fund for Subsidy of Kyushu University School of Medicine Alumni
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The lymphatic vascular systemhas been minimally explored in the liver despite its essential functions including maintenance of tissue fluid homeostasis. The discovery of specific markers for lymphatic endothelial cells has advanced the study of lymphatics by methods including imaging, cell isolation, and transgenic animal models and has resulted in rapid progress in lymphatic vascular research during the last decade. These studies have yielded concrete evidence that lymphatic vessel dysfunction plays an important role in the pathogenesis of many diseases. This article reviews the current knowledge of the structure, function, and markers of the hepatic lymphatic vascular system as well as factors associated with hepatic lymphangiogenesis and compares liver lymphatics with those in other tissues.
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