Journal
CHEMISTRYSELECT
Volume 2, Issue 30, Pages 9882-9887Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201701963
Keywords
basicity; chirality; host-guest interaction; proton sponge; Troger's base
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Funding
- Russian Foundation for Basic Research [16-33-60037]
- Research Foundation - Flanders (FWO)
- Hercules Foundation
- Flemish Government - department EWI
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Proton sponge analogue of the Troger's base (4) has been obtained upon treatment of 1-amino-4,5-bis(dimethylamino)naphthalene with paraformaldehyde. It was found that in contrast to classical Troger's base 1, protonation of 4 occurs, at least thermodynamically, exclusively on peri-NMe2 groups producing a dication with two chelated [NHN](+) hydrogen bonds. This prevents the protonation of the bridge nitrogen atoms, which is responsible for rather easy racemization of 1. Indeed, two enantiomers of 4 were resolved by chiral chromatography and their much higher stability in acidic media as compared to 1 has been confirmed. Some other properties of base 4 including structure, basicity, dynamic NMR behavior, host-guest interactions and reactions with electrophiles are also discussed.
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