Journal
CHEMISTRYSELECT
Volume 2, Issue 35, Pages 11380-11383Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201702398
Keywords
Addition; catalyst-free; chroman; quinone methides; spirocycle
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Funding
- National Key Research and Development Program of China [2016YFA0501403]
- Special Funds for the Development of Strategic Emerging Industries in Shenzhen [VJCYJ20160429191918729]
- South University of Science and Technology of China
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We have reported herein a catalyst-free cycloaddition of ortho-hydroxyphenyl-substituted para-quinone methides and 2-arylideneindane-1,3-diones by which a series of chromans featuring a spiro indane-1,3-dione scaffolds were obtained in high yields without any additives. Importantly, both anti- and syn- diastereomers could be obtained as single diastereomers respectively. Moverover, the current methold provides a novel and convenient approach for the efficient incorporation of the two biologically important scaffolds (chroman and spiro indane-1,3-dione).
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