Journal
CHEMISTRYSELECT
Volume 2, Issue 33, Pages 10782-10785Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201702220
Keywords
4-Aminoquinoline-Phthalimides; Anti-Tubercular Evaluation; Cytotoxicity; Microwave
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Funding
- Council of Scientific and Industrial research (CSIR), New Delhi, India, under CSIR-JRF Fellowship [09/254(0269)/2017-EMR-1]
- Science and Engineering Research Board (SERB), New Delhi [EMR/2015/001687]
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Microwave assisted synthesis of 4-aminoquinoline-phthalimides was carried out in order to probe their anti-tubercular potential. Different conditions were screened both under conventional and microwave heating and the best results were obtained by microwave heating in DMSO at 160 degrees C for 2 min affording the desired 4-aminoquinoline-phthalimides in quantitative yields. Anti-tubercular evaluation against mc(2)6230 strain of Mycobacterium tuberculosis revealed 3e, having an octyl chain length as spacer, to be the most potent of the synthesized compounds exhibiting MIC99 of 13.7 mu M.
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