Journal
CHEMISTRYSELECT
Volume 2, Issue 21, Pages 6154-6158Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201700819
Keywords
Green protocol; Multicomponent; Microwave method; Solvent free
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Funding
- UGC, New Delhi
- DST, New Delhi
- RGNF fellowship scheme
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Microwave-assisted synthesis of pyrrolo[1,10]-phenanthrolines in a one pot four component approach afforded a wide range of products within 3 minutes. All the compounds were screened for their biological activities such as anti-microbial and anti-cancer activities. Compounds 5b, 5c, 5i, 5m and 5n have shown more potent activity when compared to standard doxorubicin against AGS cancer cell line and compounds 5d and 5l show more potent microbial activity against MRSA, B. Subtilis and C. Albicans when compared to standard Erythromycin, Oxacillin and Ketoconazole
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