Journal
CHEMISTRYSELECT
Volume 2, Issue 32, Pages 10435-10441Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201702144
Keywords
antioxidant; inhibitor; NMR; polyphenol oxidase; virtual screening
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Funding
- University of Auckland
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Polyphenol oxidases (PPOs) are enzymes that catalyse the oxidation of phenolic compounds. We report a NMR-based assay that can be used as a screening and validation tool for PPO activity modulators, which was demonstrated using a series of PPO inhibitors and antioxidants. This method is exemplified by work in tandem with virtual screening and molecular modelling, which led to the discovery of several novel PPO inhibitors.
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