Synthesis and Antitumoral Lung Carcinoma A549 and Antioxidant Activity Assays Of New Chiral β-Aryl-Chalcogenium Azide Compounds

The synthesis of chiral azido organochalcogenium compounds prepared from inexpensive and commerciallyavailable alpha-amino alcohols through diazo transfer reaction are disclosed. The products were obtained in good yields in a modulate synthetic route, affording an efficient methodology for preparing new chiral beta-aryl-chalcogenium azide compounds. These com-pounds were evaluated for in vitro antitumoral lung carcinoma A549 as well as electrochemical and antioxidant assays. They presented prominent activities of apoptosis and cell cycle arrest induction as well as antioxidant properties. Additionally, the toxicities in vivo for the most effective compounds were evaluated and no overt sign of toxicity was observed.