Journal
CHEMISTRYSELECT
Volume 2, Issue 10, Pages 3009-3013Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201700292
Keywords
biomaterials; hydrogel; injectable; Laponite; nonswellable
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Funding
- Sao Paulo Research Foundation [2013/11519-7]
- National Council for the Improvement of Higher Education (CAPES)
- National Council for Scientific and Technological Development (CNPq) [302453/2014-8]
- Brazilian Synchrotron Light Laboratory (LNLS) at CNPEM, Campinas, Brazil
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Injectable hydrogels have gained interest as drug delivery systems for the controlled release of drugs at specific locations. A simple strategy to obtain versatile supramolecular hydrogels has been developed, yielding transparent, self-standing, nonswellable, biocompatible, biodegradable, shear-thinning and self-healing hydrogels. The gelification process occurs within seconds through ionic interactions between inorganic nanodiscs, an organic polymer and phosphate buffer solution. This strategy enables the inclusion of virtually any water-soluble moiety, because there is no addition of organic solvents, metal catalysts, radical initiators or ultraviolet radiation. The new hydrogels present a shear storage modulus up to G'- 1.3x10(4) Pa, one of the largest among those reported for non-covalent hydrogels. The nonswelling and shear-thinning behavior are crucial properties to the application of these new materials as injectable hydrogels.
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