Journal
GENES & DISEASES
Volume 3, Issue 3, Pages 220-227Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.gendis.2016.05.001
Keywords
Alzheimer's disease; Antioxidant; Biogenesis; Dynamics; Mitochondria; mtDNA; Therapy
Funding
- National Natural Science Foundation of China (NSFC) [81171197, 81220108010]
- Bureau of Health of Chongqing Medical Research Grant [2011-1-018]
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Alzheimer's disease (AD) remains the most common neurodegenerative disease characterized by beta-amyloid protein (A beta) deposition and memory loss. Studies have shown that mitochondrial dysfunction plays a crucial role in AD, which involves oxidative stress-induced respiratory chain dysfunction, loss of mitochondrial biogenesis, defects of mitochondrial dynamics and mtDNA mutations. Thus mitochondria might serve as drug therapy target for AD. In this article, we first briefly discussed mitochondrial theory in the development of AD, and then we summarized recent advances of mitochondrial abnormalities in AD pathology and introduced a series of drugs and techniques targeting mitochondria. We think that maintaining mitochondrial function may provide a new way of thinking in the treatment of AD. Copyright (C) 2016, Chongqing Medical University. Production and hosting by Elsevier B.V.
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