Journal
RSC ADVANCES
Volume 6, Issue 86, Pages 82553-82565Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra12463a
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In cancer therapy, smart nanocarriers are one of the most important nanoscale vectors of therapeutic agents. In this study, magnetic carbon nanotubes are functionalized with stimuli-responsive polymeric shells, which have thermal sensitivity and redox sensitivity due to the presence of PNIPAM-co-PHEMA and disulfide bonds, respectively. The chemical-physical properties of the nanovectors have been specified and used in a pinpointed DOX delivery system. At 25 degrees C, 12% of DOX was released from poly(NIPAM-HEMA-SS)/MN-MWCNTs in 12 h; as the temperature increased to 41 degrees C, the cumulative release amount of DOX in 12 h increased to 41%. Moreover, it was shown that in the presence of DTT, a more rapid release rate of DOX was observed. The in vitro hemolysis and in vivo biochemical analysis results revealed negligible toxicity of poly(NIPAM-HEMA-SS)/MN-MWCNTs in mice at a high dosage in the course of a 10 day experiment. The temperature responsive cytotoxicity of DOX-poly(NIPAM-HEMA-SS)/MN-MWCNTs was determined in vitro. In addition, with increasing temperature, the viability significantly decreased; the cell survival ratio was reduced from 59% +/- 1% at 37 degrees C to 50% +/- 2% at 41 degrees C at a concentration of 2 mu g mL(-1) because of the increased drug release under these conditions, likely as it was observed during in vitro drug release.
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