Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 9, Pages -Publisher
MDPI AG
DOI: 10.3390/ijms17091401
Keywords
ALG-2; ALIX; calcium; COPII; ESCRT; membrane repair; multivesicular body; PDCD6; protein-protein interaction; Sec31A
Funding
- Japan Society for the Promotion of Science (JSPS) [26292050, 15K07384, 15K18680]
- Grants-in-Aid for Scientific Research [15K18680, 26292050, 15K07384] Funding Source: KAKEN
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ALG-2 (gene name: PDCD6) is a penta-EF-hand Ca2+-binding protein and interacts with a variety of proteins in a Ca2+-dependent fashion. ALG-2 recognizes different types of identified motifs in Pro-rich regions by using different hydrophobic pockets, but other unknown modes of binding are also used for non-Pro-rich proteins. Most ALG-2-interacting proteins associate directly or indirectly with the plasma membrane or organelle membranes involving the endosomal sorting complex required for transport (ESCRT) system, coat protein complex II (COPII)-dependent ER-to-Golgi vesicular transport, and signal transduction from membrane receptors to downstream players. Binding of ALG-2 to targets may induce conformational change of the proteins. The ALG-2 dimer may also function as a Ca2+-dependent adaptor to bridge different partners and connect the subnetwork of interacting proteins.
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