Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms17091508
Keywords
Toll-like receptor; TLR modulators; virtual screening; drug discovery; computational approaches
Funding
- Spanish Ministry for Economy and Competitiveness (MINECO) [CTQ2014-57141-R, BES-2012-053653]
- European Commission [H2020-MSC-ETN-642157]
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This review aims to summarize the latest efforts performed in the search for novel chemical entities such as Toll-like receptor (TLR) modulators by means of virtual screening techniques. This is an emergent research field with only very recent (and successful) contributions. Identification of drug-like molecules with potential therapeutic applications for the treatment of a variety of TLR-regulated diseases has attracted considerable interest due to the clinical potential. Additionally, the virtual screening databases and computational tools employed have been overviewed in a descriptive way, widening the scope for researchers interested in the field.
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