Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 3, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2015.1077922
Keywords
Glioma; IDH1; metabolic reprogramming; pyruvate dehydrogenase; 2-HG
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Funding
- Terry Fox Research Institute and Foundation
- NIH [R01CA172845, R01CA154915, R21CA161545]
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Mutations in isocitrate dehydrogenase 1 (IDH1) characterize most adult low-grade gliomas. Mutant IDH1 catalyzes production of the oncometabolite 2-hydroxyglutarate (2-HG). We recently discovered that the IDH1 mutation also reprograms pyruvate metabolism in a 2-HG-dependent manner, and that reprogramming of pyruvate metabolism is essential for cell proliferation in glioma cells with mutant IDH1.
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