In vitro and in vivo anti-oxidation and anti-fatigue effect of monkfish liver hydrolysate

Monkfish liver, which is rich in protein, has high nutritious and medicinal value. Moreover, in recent studies, properties of bioactive peptides hydrolysates that make potential ingredients of health functional foods. In this study, monkfish liver hydrolysates (MLH) produced commercially enzyme. The in vivo and in vitro antioxidant activity and anti-fatigue activity of MLH were determined. The test of climbing endurance of mice were performance after one and half months of MLH administration in the anti-fatigue activity. After six weeks of MLH administration, mice were then sacrificed and assessed for biochemical parameters, SOD activity and MDA content in hepatic and kidney homogenates. Results showed that MLH contained the amino acids and peptides, which were expected to contribute to its antioxidant and anti-fatigue activities. The climbing period of experimental groups was increased compared with that of Control group. And execution with MLH could significantly increase SOD activity in hepatic and kidney. MDA contents of hepatic and kidney homogenate in the Aging Model had a higher level. MLH could significantly alleviate fatigue of the mice and had an anti-oxidative effect on aging mice. Conclusively, monkfish liver hydrolysates may be a beneficial ingredient to use in functional foods, indicating that monkfish liver is valuable for further study.