Journal
RSC ADVANCES
Volume 6, Issue 92, Pages 89413-89416Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra20732d
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Funding
- National Natural Science Foundation of China [21522604, U1463201, 21402240]
- youth in Jiangsu Province Natural Science Fund [BK20150031, BK20130913, BY2014005-03]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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A one-pot oxidative amidation of both aliphatic and aromatic alcohols with N-chloramines, prepared in situ from many types of primary and secondary amines, was developed. This cross-coupling reaction integrates alcohol oxidation and amide bond formation, which are usually accomplished separately, into a single operation. And it was green, simple and convenient, which has a wide substrate scope and makes use of cheap, abundant, and easily available reagents. The practical value of this method is highlighted through the synthesis of a high-profile pharmaceutical agent, acetylprocainamide.
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