Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 3, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2015.1056331
Keywords
Alpha-ketoglutarate; cancer-associated; fibroblast; IDH; metabolic symbiosis; metastasis; tumor microenvironment
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Funding
- NIH [RO1s CA125454, CA188118]
- DOD Breakthrough Award [BC140733P1]
- Mary Kay Ash Foundation
- National Natural Science Foundation of China [81402432]
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Cancer-associated fibroblasts (CAFs) are major participants in the crosstalk between tumor cells and their microenvironment. CAFs provide not only multiple soluble factors but also metabolic fuels to promote tumor growth, invasion, and metastasis. We discuss recent developments delineating the effects of metabolic symbiosis between CAFs and tumor cells on tumor growth.
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