Journal
ROYAL SOCIETY OPEN SCIENCE
Volume 4, Issue 7, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsos.170352
Keywords
biomimetic semisynthesis; structural elucidation; selaginellins; alkynylphenol; Selaginella tamariscina
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Funding
- National Natural Science Foundation of China [U1502223, 81603000, 21602227]
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Two new lactone-containing selaginellins T and U (1 and 2) together with eleven known selaginellin derivatives (3 and 7-16) were isolated from the whole plant of Selaginella tamariscina. The structure of tautomeric selaginellin U along with its biogenetic pathway was confirmed and proposed by a cross-validation of the semisynthesis of compound 4 from selaginellin (3) and derivation from 2 to 4. Additionally, compounds 3, 13 and 16 exhibited good inhibitory activities against beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) with IC50 values of 81.17, 51.13 and 48.89 mu M, respectively.
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