Journal
DIABETES THERAPY
Volume 8, Issue 5, Pages 1187-1190Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s13300-017-0289-9
Keywords
Cystic fibrosis; Cystic fibrosis-related diabetes; Diabetes in infancy; Glargine; Glucose metabolism derangements; Infant
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Diabetes mellitus is the most common comorbidity in cystic fibrosis (CF). Recently, more attention has been paid to early glucose metabolism derangements (GMDs). The subject of this report is a female patient, affected by CF since 3 months of age. She presented with intermittent diabetes during early childhood. At the age of 10 years, oral glucose tolerance test (OGTT) was performed and showed glucose intolerance (IGT) status; glargine insulin therapy was started. At the age of 13 years, CF-related diabetes with fasting hyperglycemia occurred, so rapid insulin at meals was added. During the following year, clinical and nutritional status improved. Stable clinical conditions were observed in the following 3 years. This is the first case of very long-term follow-up concerning a CF patient with GMDs. Our case confirms the importance of paying attention to early GMDs in very young CF patients and seems to suggest that earlier therapy could ameliorate CF natural history.
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