Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 3, Issue 12, Pages 3628-3634Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00405
Keywords
targeted drug delivery; orthotopic bladder tumor; chemo-photothermal therapy; near-infrared; tumor vasculature
Categories
Funding
- National Natural Science Foundation of China [21574136, 21390411, 81573110]
- Hundred Talents Program of Chinese Academy of Sciences
- Youth Innovation Promotion Association Program of Chinese Academy of Sciences [2015008]
- 863 Program [2012AA02A407]
- Key Science and Technology Innovation Team of Zhejiang Province
- Natural Science Foundation of Zhejiang Province [Y2110580, LY12C07001, LY13H100003, LZ14H260001]
- Scientific Research Fund of Ministry of Public Health [201231029]
- Zhejiang Provincial Major Research Program [2010C13007]
- National Natural Science Foundation of China [21574136, 21390411, 81573110]
- Hundred Talents Program of Chinese Academy of Sciences
- Youth Innovation Promotion Association Program of Chinese Academy of Sciences [2015008]
- 863 Program [2012AA02A407]
- Key Science and Technology Innovation Team of Zhejiang Province
- Natural Science Foundation of Zhejiang Province [Y2110580, LY12C07001, LY13H100003, LZ14H260001]
- Scientific Research Fund of Ministry of Public Health [201231029]
- Zhejiang Provincial Major Research Program [2010C13007]
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Nanomedicines have shown great promise in increasing the efficacy and preventing adverse effects of drugs for bladder cancer. Here we sought to examine the effect of chemo-photothermal therapy on an orthotopic mouse model of superficial bladder cancer. Doxorubicin (DOX) was encapsulated in CS/PNIPAAm@SWCNTs nanoparticles. The biodistribution and antitumor effects of DOX-loaded nanoparticles were analyzed. DOX-loaded nanoparticles were accumulated in tumor cells upon near-infrared (NIR) irradiation and exhibited strong antitumor activity in mice bearing orthotopic bladder tumors. In addition, NIR-induced hyperthermia enhanced the permeability of tumor blood vessels, which presumably accounted for specific targeting of the nano medicines to tumors. These results suggest that NIR-guided thermal responsive nanomedicines are potentially applicable for chemo-photothermal therapy against orthotopic bladder tumors.
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