Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 3, Issue 9, Pages 2054-2058Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00440
Keywords
adjuvants; dendritic cells; micelles; hybrid materials; nucleic acids; DNA nanotechnology
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Funding
- Pukyong National University
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We elucidated the proper routes for injecting lipid-DNA micelles formulated with an oligonucleotide immune adjuvant in naive and tumor-bearing mice. We report herein that after assessing six ways of administering an immunostimulatory nanoparticle (INP), several of the injection routes effectively induced dendritic cell-mediated immune-stimulation in vivo, making them amenable to cancer immunotherapies and vaccines using such DNA materials.
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