Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 3, Issue 10, Pages 2293-2301Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00432
Keywords
MAX phase; Ti(2)AIN; cytocompatibility; in vitro test; first-principles calculations
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Funding
- National Natural Science Foundation of China [91226202, 91426304]
- CAS
- Ningbo Natural Science Foundation [2016A610273]
- China Scholarship Council (CSC) [201608260009]
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Herein, the cytocompatibility of selected MAX phases, Ti(3)AIC(2), Ti3SiC2, and Ti(2)AIN, were systematically evaluated using in vitro tests for the first time. These phases were anoxic to preosteoblasts and fibroblasts. Compared with the strong viable fibroblasts, the different cellular responses of these materials were clearly distinguishable for the preosteoblasts. Under an osteoblastic environment, Ti(2)AIN exhibited better cell proliferation and differentiation performance than Ti3AlC2 and Ti3SiC2. Moreover, the performance was superior to that of a commercial Ti-6Al-4V alloy and comparable to that of pure Ti. A possible mechanism was suggested based on the different surface oxidation products, which were determined from the binding energy of adsorbed Ca2+ ions using first-principles calculations. Compared with the partially oxidized TiC Oy layer on Ti(3)AIC(2) and Ti3SiC2, the partially oxidized TiNxOy layer on the Ti(2)AIN had a stronger affinity to the Ca2+ ions, which indicated the good cytocomatibility of Ti(2)AIN.
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