Journal
JOURNAL OF INTERCULTURAL ETHNOPHARMACOLOGY
Volume 5, Issue 4, Pages 343-349Publisher
EJMANAGER LLC
DOI: 10.5455/jice.20160731025522
Keywords
Anti-inflammatory activity; Barringtonia racemosa; protein denaturation inhibition; total phenolic content; xanthine oxidase inhibition
Categories
Ask authors/readers for more resources
Aim: This study was conducted to evaluate the in vitro anti-inflammatory activities and total phenolic content (TPC) of methanolic extracts of infloresence axes, endosperms, leaves, and pericarps of Barringtonia racemosa L. Methods: The anti-inflammatory study was conducted by assessing the potential through xanthine oxidase (XO) and albumin denaturation inhibition assays. Meanwhile, the TPC in the extracts were assessed by FolinCiocalteu assay. Results: In the XO inhibition assay, the infloresence axes extract was found to exert the highest inhibition capacity at 0.1% (w/v) with 59.54 +/- 0.001% inhibition followed by leaves (58.82 +/- 0.001%), pericarps (57.99 +/- 0.003%), and endosperms (57.20 +/- 0.003%) extracts. Similarly in the albumin denaturation inhibition assay, the infloresence axes extract had shown the greatest inhibition capacity with 70.58 +/- 0.004% inhibition followed by endosperms (66.80 +/- 0.024%), leaves (65.29 +/- 0.006%), and pericarps extracts (43.33 +/- 0.002%). Meanwhile, for TPC analysis, leaves extract was found to have the highest phenolic content (53.94 +/- 0.000 mg gallic acid equivalent [GAE]/g DW) followed by infloresence axes (31.54 +/- 0.001 mg GAE/g DW), endosperms (22.63 +/- 0.001 mg GAE/g DW), and the least was found in pericarps (15.54 +/- 0.001 mg GAE/g DW). Conclusion: The results indeed verified the in vitro anti-inflammatory activities of B. racemosa and supported its potential to be used in alleviating gouty arthritis and XO-related diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available