Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2017.00133
Keywords
non-alcoholic fatty liver disease; RNA splicing; hepatocellular carcinoma; splicing factors; microarrays
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Funding
- VA Merit Review award [I01BX000130]
- NIH [HD012303, CA155435, CA023100, CA196853, DK033651]
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Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent due to the worldwide obesity epidemic and currently affects one-third of adults or about one billion people worldwide. NAFLD is predicted to affect over 50% of the world's population by the end of the next decade. It is the most common form of liver disease and is associated with increased risk for progression to a more severe form non-alcoholic steatohepatitis, as well as insulin resistance, type 2 diabetes mellitus, cirrhosis, and eventually hepatocellular carcinoma. This review article will focus on the role of alternative splicing in normal liver physiology and dysregulation in liver disease.
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