Journal
INFECTION AND DRUG RESISTANCE
Volume 10, Issue -, Pages 332-341Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S144446
Keywords
Mycobacterium tuberculosis; antibiotic resistance; compensatory evolution; epistasis; efflux pumps; fitness cost
Categories
Ask authors/readers for more resources
Despite the efficacy of antibiotics to protect humankind against many deadly pathogens, such as Mycobacterium tuberculosis, nothing can prevent the emergence of drug-resistant strains. Several mechanisms facilitate drug resistance in M. tuberculosis including compensatory evolution, epistasis, clonal interference, cell wall integrity, efflux pumps, and target mimicry. In this study, we present recent findings relevant to these mechanisms, which can enable the discovery of new drug targets and subsequent development of novel drugs for treatment of drug-resistant M. tuberculosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available