Journal
SCIENCE CHINA-MATERIALS
Volume 60, Issue 10, Pages 995-1007Publisher
SCIENCE PRESS
DOI: 10.1007/s40843-017-9107-x
Keywords
curcumin; drug delivery; PLGA; metastatic; osteosarcoma
Categories
Funding
- National Natural Science Foundation of China [51520105004, 51673189, 51390484, 51403204, 51673185, 51473029, 51503202]
- Science and Technology Service Network Initiative [KFJ-SW-STS-166]
- Chinese Academy of Sciences Youth Innovation Promotion Association
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Osteosarcoma is a high-class malignant bone cancer with a less than 20% five-year survival rate due to its early metastasis potential. There is an urgent need to develop a versatile and innoxious drug to treat metastatic osteosarcoma. Curcumin (Cur) has shown its potential for the treatment of many cancers; however, the clinical implication of native curcumin is severely hindered by its intrinsic property. In this study, a mixed system of monomethoxy (polyethylene glycol)poly(d, l-lactide-co-glycolide)/poly(epsilon-caprolactone) (mPEGPLGA/ PCL) was used to build a formulation of curcumin-encapsulated nanoparticles (Cur-NPs), which significantly improved the solubility, stability and cellular uptake of curcumin. Moreover, the Cur-NPs were superior to free curcumin in the matter of inhibition on the proliferation, migration and invasion of osteosarcoma 143B cells. It was found that both free curcumin and Cur-NPs could decrease the expressions of c-Myc and MMP7 in the level of mRNA and protein, which explained why free curcumin and Cur-NPs could inhibit the proliferation and invasion of metastatic osteosarcoma 143B cells. The Cur-NPs provided a promising strategy for metastatic osteosarcoma treatment.
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