Journal
MATERIALS & DESIGN
Volume 132, Issue -, Pages 257-265Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2017.06.057
Keywords
PCL nanofibers; Plasma polymerization; Cell viability; Amine surfaces; Carboxyl-anhydride layers
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Funding
- Ministry of Education, Youth and Sports of the Czech Republic (MEYS CR) [LQ1601]
- CEITEC Nano Research Infrastructure (MEYS CR)
- COST CZ project - MEYS CR [LD15150]
- Ministry of Education and Science of the Russian Federation in the framework of Increase Competitiveness Program of NUST MISiS [K4-2016-005, N 211]
- Brno city municipality
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The plasmamodification of biodegradable nanofibers is of great interest for improvement of their biocompatibility. However, there are no systematic studies regarding the influence of plasma polymer deposition onto the surface of nanofibers to improve cell adhesion. In the present study, homogenous and reproducible modification of polycaprolactone (PCL) nanofibers by amine and carboxyl/anhydride groupswas achieved. The concentration of amines NH2/C and C(O)O contribution were up to 2.9 and 14.1%, respectively. Regardless the plasma conditions, the deposition of amine and carboxyl-anhydride plasma coatings onto the PCL nanofibers sufficiently improved the cell adhesion and viability, as was evidenced by microscopy observations and ATP assay results. It should be emphasized that the deposition of negatively charged carboxyl-anhydride coatings resulted in slightly better cell adhesion compared to the positively charged amine plasma coatings, unlike the widespread opinion that COOH modification has less effect on myoblasts adhesion. (C) 2017 Elsevier Ltd. All rights reserved.
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