Journal
CELL SYSTEMS
Volume 4, Issue 3, Pages 344-356Publisher
CELL PRESS
DOI: 10.1016/j.cels.2017.01.013
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Funding
- Intramural Research Program of the National Cancer Institute (Center for Cancer Research)
- National Library of Medicine of the NIH
- Intramural Research Program of National Institute of Arthritis and Musculoskeletal and Skin Diseases (NAIMS)
- National Science Foundation [DBI-08-50214]
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DNA in cells is predominantly B-form double helix. Though certain DNA sequences in vitro may fold into other structures, such as triplex, left-handed Z form, or quadruplex DNA, the stability and prevalence of these structures in vivo are not known. Here, using computational analysis of sequence motifs, RNA polymerase II binding data, and genomewide potassium permanganate-dependent nuclease footprinting data, we map thousands of putative non-B DNA sites at high resolution in mouse B cells. Computational analysis associates these non-B DNAs with particular structures and indicates that they form at locations compatible with an involvement in gene regulation. Further analyses support the notion that non-B DNA structure formation influences the occupancy and positioning of nucleosomes in chromatin. These results suggest that non-B DNAs contribute to the control of a variety of critical cellular and organismal processes.
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