Journal
OPEN MEDICINE
Volume 12, Issue 1, Pages 171-176Publisher
DE GRUYTER OPEN LTD
DOI: 10.1515/med-2017-0025
Keywords
Nasopharyngeal carcinoma; Epstein-Barr virus; LMP1; MicroRNAs
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Southern China experiences larger extent of total cancer pathologies, of which nasopharyngeal carcinoma has the highest incidence under otorhinolaryngeal malignant carcinomas. Risk factor of nasopharyngeal carcinoma varies from hereditary causes to virus infection, among which Epstein-Barr virus (EBV) infection is the mostly investigated. The study into mechanism of EBV in occurrence, development and prognosis of nasopharyngeal carcinoma has been studied for several decades. The pathophysiology in making of EBV into a cancerogen includes proteins as latent membrane protein 1 (LMPs) and nucleic acids as micro-RNAs. In this paper, we reviewed till date studies focusing on relationship between EBV and nasopharyngeal carcinoma.
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