Journal
CANCER GENOMICS & PROTEOMICS
Volume 13, Issue 6, Pages 475-482Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/cgp.20010
Keywords
BIM; non-small cell lung cancer; epidermal growth factor receptor tyrosine kinase inhibitor
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Funding
- JSPS [JP15K09195, JP2642140]
- Toho University Graduate School of Medicine [16-3]
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Aim: This pilot study assessed the association of BIM deletion polymorphism and BIM RNA isoform in patients with EGFR-positive non-small cell lung cancer (NSCLC). Patients and Methods: The study included 33 patients with EGFR-positive NSCLC treated with gefitinib. BIM deletion polymorphism and BIM RNA isoform (EL/L/S/gamma) were determined by polymerase chain reaction (PCR). Results: BIM-gamma expression was significantly higher in patients with BIM deletion polymorphism than among those without BIM deletion polymorphism inside tumors (p=0.038) and around tumors (p=0.0024). Relative BIM-gamma expression was significantly higher in patients with BIM deletion polymorphism than among those without BIM deletion polymorphism (p=0.0017). Patients with BIM-. had significantly shorter progression-free survival than those without BIM-. (median: 304 vs. 732 days; p=0.023). Conclusion: Expression of BIM-. mRNA and BIM deletion polymorphism were strongly associated. BIM-. overexpression may have a role in apoptosis related to EGFR-tyrosine kinase inhibitor.
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