Journal
TRANSLATIONAL CANCER RESEARCH
Volume 6, Issue -, Pages S852-S874Publisher
AME PUBL CO
DOI: 10.21037/tcr.2017.06.47
Keywords
Radiation therapy (RT); radiation toxicity; omics
Categories
Funding
- INFN CSN5 Project Proposal: ETHICS (Pre-clinical Experimental and THeoretical studies to Improve treatment and protection by Charged particleS)
- INFN CSN5 Project Proposal: MoVe IT (Modeling and Verification for Ion beam Treatment planning)
Ask authors/readers for more resources
The goal of radiation therapy (RT) is to deliver the therapeutic dose to target tissues minimizing the risks of normal tissue complication. Nowadays, technological advances in radiation delivery and the introduction of particle therapies have strongly limited the amount of dose distributed to normal tissues and enhanced the tumor killing capacity. Here, we discuss about the state of art in RT treatment modalities, tumor sensitivity and radiation toxicity. A special insight is dedicated to the role of tumor heterogeneity, cancer stem cells (CSCs) and hypoxia. In addition, in this review we provide an overview of the most recently studies evaluating the potential role of omic biomarkers for a personalized biological-driven treatment planning, useful to maximize the radiotherapy success without normal tissues complications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available