Journal
TRANSLATIONAL CANCER RESEARCH
Volume 6, Issue 6, Pages 1050-1060Publisher
AME PUBL CO
DOI: 10.21037/tcr.2017.08.23
Keywords
Intravoxel incoherent motion (IVIM); magnetic resonance imaging (MR imaging); rectal cancers; histopathological features
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Funding
- Medical Science and technology development Foundation, Nanjing Department of Health [YKK15067]
- National Health and Family Planning Commission of China [W201306]
- National Natural Science Foundation of China [81371516, 81601463]
- Six Talent Peaks Project of Jiangsu Province [2015-WSN-079]
- Natural Science Foundation of Jiangsu Province [BK20150109]
- Research Project of Health and Family Planning Commission of Jiangsu Province [Q201508]
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Background: To explore the role of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging in predicting the histopathological features of rectal cancers preoperatively. Methods: Forty-six patients with a diagnosis of rectal cancer through endoscopic biopsy were prospectively enrolled and underwent IVIM MR imaging (12 b values: 0-1,200 s/mm(2)) before surgery. Apparent diffusion coefficient (ADC), pure diffusion coefficient (D), perfusion-related incoherent microcirculation (D*) and perfusion fraction (f) values of the lesions were obtained and compared among rectal cancers with different histopathological features, including maximum diameter, pathological type, differentiation degree, TNM stage, lymphovascular and neural invasion status. Results: The f and D* values of rectal cancers with lymphovascular invasion (LVI) were significantly higher than those without LVI (P = 0.034, 0.037, respectively). And the LVI rate differed significantly among rectal cancers with different pN stages (P = 0.003). Conclusions: We demonstrated that the f value derived from IVIM MR imaging might be useful to predict LVI status of rectal cancers preoperatively, which required further confirmation in a larger cohort.
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