Journal
DRUG DISCOVERIES AND THERAPEUTICS
Volume 10, Issue 1, Pages 44-48Publisher
INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT
DOI: 10.5582/ddt.2016.01013
Keywords
Antifungal; silkworm infection assay; trichothecenes; Candida albicans; cytotoxicity
Categories
Funding
- JSPS KAKENHI [22590013, 25460130, 21310146]
- Grants-in-Aid for Scientific Research [22590013, 25460130] Funding Source: KAKEN
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The silkworm infection assay is a useful method for directly evaluating the in vivo therapeutic effects of drug candidates. In the present study, 3 known trichothecenes, trichodermin, epiisororidin E, and verrucarin A, were evaluated as antifungal agents in the silkworm-Candida albicans assay. Trichodermin and epiisororidin E yielded effective therapeutic effects, while verrucarin A exhibited no efficacy in this assay system. These results strongly suggest that trichodermin and epiisororidin E are the lead compounds for developing a new antifungal agent.
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