Journal
RESEARCH SYNTHESIS METHODS
Volume 8, Issue 4, Pages 392-403Publisher
WILEY
DOI: 10.1002/jrsm.1259
Keywords
network meta-analysis; multi-arm trials; multiplicity; pairwise meta-analysis
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Systematic reviewers conducting pairwise meta-analyses sometimes encounter multi-arm studies. To include these studies, and to avoid a unit-of-analysis error, often two or more arms are combined or the control arm is split. In this tutorial, we present 5 different approaches that can be used. Particularly, we present a novel approach (method 4) that to the best of our knowledge has not been presented before. We demonstrate their application on 3 selected data sets, discuss their scope of application and their advantages and limitations, and give recommendations.
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