Journal
REDOX BIOLOGY
Volume 12, Issue -, Pages 208-215Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2017.02.012
Keywords
Mitochondria; ROS; Hypoxia; HIF; Respiratory chain
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB 815]
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Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment. Mitochondria are major consumers of oxygen and a potential source of reactive oxygen species (ROS). In response to hypoxia they exchange or modify distinct subunits of the respiratory chain and adjust their metabolism, especially lowering the citric acid cycle. Intermediates of the citric acid cycle participate in regulating hypoxia inducible factors (HIF), the key mediators of adaptation to hypoxia. Here we summarize how hypoxia conditions mitochondria with consequences for ROS-production and the HIF-pathway.
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