Journal
REDOX BIOLOGY
Volume 11, Issue -, Pages 708-714Publisher
ELSEVIER
DOI: 10.1016/j.redox.2016.12.020
Keywords
Aging; Caenorhabditis elegans; Cuticle; Innate immunity; Pathogen infection; Reactive oxygen species; Redox homeostasis; ROS detection; Wound healing
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Funding
- Spanish Ministry of Economy and Competitiveness [BFU2015-64408-P]
- Instituto de Salud Carlos III [PI11/00072]
- Instituto de Salud Carlos III (Fondo Social Europeo)
- Medical Research Council [G0800082] Funding Source: researchfish
- MRC [G0800082] Funding Source: UKRI
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ROS (reactive oxygen species) are potentially damaging by-products of aerobic metabolism which, unchecked, can have detrimental effects on cell function. However, it is now widely accepted that, at physiological levels, certain ROS play important roles in cell signaling, acting as second messengers to regulate cell choices that contribute to the development, adaptation and survival of plants and animals. Despite important recent advances in the biochemical tools available to study redox-signaling, the molecular mechanisms underlying most of these responses remain poorly understood, particularly in multicellular organisms. As we will review here, C. elegans has emerged as a powerful animal model to elucidate these and other aspects of redox biology.
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